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Evaluation of T Lymphocyte Effector Function in Immunodeficiency Diseases: Abnormality in Mitogen-Stimulated Interferon in Patients with Selective IgA Deficiency¹

From the Cancer Research Institute and the Department of Pediatrics, University of California, San Francisco, California 94143

Abstract

Interferon production in response to the mitogens phytohemagglutinin and pokeweed was studied as a new index of the competence of thymus-derived (T) lymphocyte effector function in patients with various immunodeficiency states. The results indicated that three of four patients with selective IgA deficiency and normal T cell proliferative response had a depressed T cell interferon response.

Two patients who had received successful thymus transplants had a normal T cell interferon response. Before transplantation one had been diagnosed as severe combined immunodeficiency, and the other, thymic hypoplasia with normal serum immunoglobulin levels. By contrast, a patient with thymic hypoplasia and absent serum IgA, low IgM and normal IgG levels, who had had an unsuccessful thymic graft, had a markedly depressed interferon response. Normal T cell interferon responses were seen in one patient with congenital sex-linked hypogammaglobulinemia and three patients with acquired hypogammaglobulinemia.

Footnotes

¹ This work was supported by United States Public Health Service Grants CA 11067 and 5 MO1 RR 00079-10; by the Damon Runyon Memorial Fund, Grant DRG-1205; and by the John Hartford Foundation, Inc.

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