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Studies on Delayed Hypersensitivity with Trachoma Organisms

III. Lymphokines¹

From the Department of Pathobiology and the Department of Epidemiology and International Health, School of Public Health and Community Medicine, University of Washington, Seattle, Washington 98195

Abstract

Guinea pigs sensitized via the footpad with inactivated trachoma organisms in complete Freund's adjuvant developed delayed hypersensitivity to trachoma at the 9th day as demonstrated by skin tests and in vitro blastogenic transformation of lymphocytes obtained from the regional lymph nodes. The supernatant of lymph node lymphocytes cultured in the presence of trachoma antigen for 24 hr and concentrated 10-fold induced erythema in the normal guinea pig skin. Similar supernatant cultured for 5 days was shown to inhibit the growth of the mouse L cell at a 1:4 dilution.

Footnotes

¹ This study was supported by United States Public Health Service Research Grant 5-R01-EY-00219 from the National Eye Institute.