HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Gorczynski, R. M. Search for Related Content PubMed Articles by Gorczynski, R. M.

Evidence for in Vivo Protection against Murine-Sarcoma Virus-Induced Tumors by T Lymphocytes from Immune Animals¹

From the Tumour Immunology Unit, Imperial Cancer Research Fund, London University College, Zoology Department, Gower Street, London, WCIE 6BT, England

Abstract

Normal 3- to 4-week old BALB/c mice inoculated with murine sarcoma virus (MSV) develop sarcomas within 7 to 10 days, which generally regress by day 15 to 20. Sublethal irradiation of the recipients, prior to inoculation of MSV, leads to the development of progressively growing tumors and ultimate death of the host within 30 days. Small numbers (1 x 10⁷) of spleen cells from mice whose tumor has regressed, but not similar numbers of cells from age-matched control mice, protect these irradiated mice from developing progressively growing tumors. Pretreatment of the protecting cells with anti- antibody and complement, but not with anti-immunoglobulin antibody and complement, abolishes the protective effect.

Footnotes

¹ This work was supported by an Imperial Cancer Research Fund grant to Professor N. A. Mitchison.

² Postdoctoral fellow of Imperial Cancer Research Fund.