HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Sharp, G. C. Articles by Kyriakos, M. Search for Related Content PubMed Articles by Sharp, G. C. Articles by Kyriakos, M.

Production of Augmented Experimental Autoimmune Thyroiditis Lesions by Combined Transfer of Antiserum and Lymph Node Cells¹

From the Division of Immunology and Rheumatology and the Department of Medicine, University of Missouri School of Medicine, Columbia, Missouri 65201 and the Department of Pathology, Washington University School of Medicine, St. Louis, Missouri 63110

Abstract

Combined transfer of thyroid-sensitized lymph node cells and hyperimmune rabbit antiserum to guinea pig thyroglobulin in inbred strain 13 guinea pigs resulted in a higher incidence and greater severity of experimental autoimmune thyroiditis than that which followed transfer of cells or serum alone. The lesions produced by combined transfer of cells and antiserum were comparable to lesions induced by active immunization of strain 13 animals. These data provide evidence for the participation of both cellular and humoral factors in the pathogenesis of autoimmune thyroiditis.

Footnotes

¹ This work was supported in part by United States Public Health Service Grant AM 15011 from the National Institutes of Health.

² Professor of Medicine, Director, Division of Immunology and Rheumatology, University of Missouri School of Medicine, Columbia, Missouri 65201.

³ Instructor, Department of Medicine, University of Missouri School of Medicine, Columbia, Missouri 65201.

⁴ Assistant Professor of Pathology, Washington University School of Medicine, St. Louis, Missouri 63110.