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Protection against Autoimmune Thyroiditis in Guinea Pigs by Thyroglobulin Antiserum^1,2,3,

From the Division of Immunology and Rheumatology and the Department of Medicine, University of Missouri School of Medicine, Columbia, Missouri 65201, Department of Medicine, Stanford University School of Medicine, Stanford, California 94305, and Department of Pathology, Washington University School of Medicine, St. Louis, Missouri 63110

Abstract

Repeated administration of hyperimmune rabbit antiserum to guinea pig thyroglobulin (GPTG) consistently protected guinea pigs from developing autoimmune thyroiditis when studied 23 days following active immunization with GPTG in complete Freund's adjuvant. Rabbit antisera to various non-thyroid antigens were much less effective in causing inhibition. The suppressive effect noted with antiserum to keyhole limpet hemocyanin (KLH) differed from anti-GPTG suppression in that it was transient and associated with reduced delayed hypersensitivity to GPTG. Protective effects of anti-GPTG persisted at 156 days even in the presence of intact delayed hypersensitivity to GPTG. Transfer of hyperimmune anti-GPTG during the first 10 days after active immunization still resulted in protection, but hyperimmune anti-GPTG given late or early anti-GPTG given throughout the experiment failed to protect.

Footnotes

¹ This work was supported in part by United States Public Health Service Grants AM 15011 and AM 05425 from the National Institutes of Health.

² A portion of this work was presented at the Interim Meeting of the American Rheumatism Association, Atlanta, Georgia, December 6, 1968.

³ A considerable portion of this work was carried out when Dr. Sharp, Dr. Wortis, and Dr. LaRoque were in the Department of Medicine, Stanford University School of Medicine.

⁴ Professor of Medicine, Director, Division of Immunology and Rheumatology, University of Missouri School of Medicine, Columbia, Missouri 65201.

⁵ Department of Medicine, Stanford University School of Medicine, Stanford, California 94305.

⁶ Present address: Department of Pathology, Tufts University School of Medicine, Boston, Massachusetts 02111.

⁷ Instructor, Department of Medicine, University of Missouri School of Medicine, Columbia, Missouri 65201.

⁸ Assistant Professor of Pathology, Washington University School of Medicine, St. Louis, Missouri 63110.