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Serum Factors in Mammary Neoplasia: Enhancement and Antagonism of Spleen Cell Activity in Vitro Detected by Different Methods of Serum Factor Assay¹

From the Department of Bacteriology and Immunology, and the Cancer Research Laboratory, University of California, Berkeley, California 94720

Abstract

Spleen cells from female mice bearing progressively-growing MTV-induced mammary tumors reduced tumor cell survival in microcytotoxicity tests. Serum from these females contained blocking factors which inhibited spleen cell activity either partially or completely, depending upon the method of serum assay, whenever serum and target cells had not been obtained from the same donor. Serum obtained from target cell donors had a reverse effect when tested by two of three serum assay methods; tumor cell survival was significantly decreased. More than one type of mammary tumor cell antigen (and host response) was detected in these tests.

Footnotes

¹ This work was supported by Public Health Service Research Grant CA-05388 from the National Cancer Institute, and by cancer research funds of the University of California.