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Thymus-Dependent (T) Lymphocytes in the Rat¹

From the Department of Experimental Pathology, Scripps Clinic and Research Foundation, La Jolla, California 92037

Abstract

Thymus-dependent (T) lymphocytes in the rat may be recognized by their reactions with fluorescein-labeled heteroantibodies and by their functional activities. The Ig fractions of horse and rabbit antisera to rat thymocytes, when labeled with fluorescein, stained more than 95% thymocytes, less than 2% bone marrow cells, and 30 to 60% of the lymphocytes in peripheral blood, lymph nodes and spleen, and did not stain IgG-bearing lymphocytes. Cell-mediated cytotoxicity and stimulation by PHA and Con A were eliminated by these heteroantisera and C in vitro; survival of skin allografts was prolonged in vivo. T lymphocytes in the rat resembled, by analogy, T lymphocytes in the mouse.

Footnotes

¹ This is Publication 731 from the Department of Experimental Pathology, Scripps Clinic and Research Foundation, La Jolla, California. The work was supported by United States Public Health Service Grant AI-07007 and Atomic Energy Commission Contract AT (04-3)-779.

² Supported by National Institutes of Health Training Grant (GM01924-04).

³ Present address: Department of Surgery, University of Alabama Medical Center, Birmingham, Alabama 35233.