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Successful Treatment of Experimental Allergic Encephalomyelitis (EAE) in Guinea Pigs with Homologous Myelin Basic Protein

From the Section on Myelin Chemistry, Laboratory of Cerebral Metabolism, National Institute of Mental Health, Bethesda, Maryland 20014, and the Department of Pathology, University of Washington School of Medicine, Seattle, Washington 98195

Abstract

Homologous myelin basic protein has been used successfully for treatment of experimental allergic encephalomyelitis (EAE) in NIH and strain 13 guinea pigs. Response of strain 13 guinea pigs to both induction and treatment of EAE was more consistent than response of outbred, NIH guinea pigs. Serum levels of antibasic protein antibody were related to the amount of mycobacteria used for sensitization rather than to disease severity or success of treatment.

Footnotes

¹ Supported by Grant 828-A-4 from the National Multiple Sclerosis Society.

² Supported in part by Research Grant NS-03147-12 from the National Institute of Neurological Diseases and Stroke, United States Public Health Service, and by Research Grant 427-E-12 from the National Multiple Sclerosis Society.

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