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Chronic Virus Infection and Immune Responsiveness

II. Lactic Dehydrogenase Virus Infection and Immune Response to Non-Viral Antigens¹

From the Department of Experimental Pathology, Scripps Clinic and Research Foundation, La Jolla, California 92037

Abstract

Differences in the immune responsiveness of infected mice against one antigen do not necessarily indicate differences in their total immunologic capacities. Antibodies formed to a variety of antigens in mice infected with lactic dehydrogenase virus (LDV) were compared to those made in uninfected mice. The antigens used were keyhole limpet hemocyanin (KLH), human IgG (HuIgG) and goat red blood cells (GRBC). Against KLH, LDV infected mice made lower immune responses than did uninfected controls, whereas against HuIgG, the immune responses of LDV infected mice were elevated over controls. The formation of antibody to HuIgG was enhanced only soon after primary immunization, was associated with an increased number of direct antibody forming cells in the spleen, and was predominantly of the IgM class. Mice infected with LDV and uninfected mice made similar immune responses to large doses of GRBC, whereas when doses of GRBC were reduced infected mice made lower immune responses.

Footnotes

¹ This is publication 730 from the Department of Experimental Pathology, Scripps Clinic and Research Foundation, La Jolla, California. This research was supported by a Violet June Kertell Memorial grant for Research on Multiple Sclerosis from the National Multiple Sclerosis Society, United States Public Health Service Grants AI-09484 and AI-07007, American Cancer Grant T-519 and Atomic Energy Commission Contract AT(04-3)-410.

² Recipient of Career Development Award AI-42580 AID from the United States Public Health Service.

³ Supported by a Dernham Senior Fellowship (D202) of the American Cancer Society, California Division.