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Preformed Eosinophil Chemotactic Factor of Anaphylaxis (ECF-A)¹

From the Departments of Medicine, Harvard Medical School and the Robert B. Brigham Hospital, Boston, Massachusetts 02120

Abstract

The eosinophil chemotactic factor of anaphylaxis (ECF-A), previously recognized as being released from sensitized human or guinea pig lung tissue by antigen challenge, has been demonstrated to exist preformed in these tissues and in isolated rat mast cells. The presence of performed ECF-A in the mast cell of the rat was established by the full recovery of ECF-A with mast cells purified from a mixed peritoneal cell population and cellular subfractionation which revealed the preformed ECF-A to be largely associated with the mast cell granules. The sum of the ECF-A released by antigen and that remaining in the sensitized challenged human or guinea pig lung tissue or isolated rat mast cells equalled that extractable from the equivalent unchallenged lung tissue or rat mast cells, indicating that the ECF-A available exists entirely in a preformed state.

Footnotes

¹ Supported by Grants AI-07722 and AI-10356 from the National Institutes of Health and a grant from the John A. Hartford Foundation, Inc.

² Postdoctoral trainee supported by Training Grant AI-00366 from the National Institutes of Health.

³ Investigator of the Howard Hughes Medical Institute.

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