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Decreased Response of Cultured New Zealand Mouse Spleen Cells to Sheep Erythrocytes¹

From the Departments of Genetics and Bacteriology and Immunology, University of California, Berkeley, California, and The Section of Clinical Immunology and Arthritis, Veterans Administration Hospital, San Francisco, California

Abstract

New Zealand (NZ) mice give excessive immune responses when immunized in vivo with sheep red blood cells (SRBC). Spleen cells of young New Zealand Black and New Zealand Black/White hybrid mice developed low primary responses compared to conventional strains when immunized in vitro. These low responses could be raised to levels achieved by other strains by adding peritoneal cells and 2-mercaptoethanol to the NZ spleen cultures. Studies of the peritoneal cells indicate that the restoring activity is a property of the adherent population and that it is not due to thymus derived lymphocytes.

Footnotes

¹ This work was supported by a research grant from the Veterans Administration and by United States Public Health Service Grant AI0-8817.

² Recipient of National Institutes of Health Genetics Fellowship SDSCF 233006-7 through the San Diego State University Foundation.

³ Genetics Department, University of California, Berkeley, California.

⁴ Division of Clinical Immunology and Arthritis, Veterans Administration Hospital, San Francisco, California.

⁵ Department of Bacteriology and Immunology, University of California, Berkeley, California.