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From the Departments of Dentistry and Dental Research and of Radiation Biology and Biophysics, School of Medicine and Dentistry, University of Rochester, Rochester, New York 14642
Abstract
An experimental autoallergic sialadenitis of the submandibular glands of the Lewis rat has been induced by immunization with allogeneic submandibular gland homogenate and adjuvants. The severity, incidence and duration of the of the lesion were significantly greater when female allogeneic submandibular gland donors were sexually mature rather than sexually immature. Passive transfer of lymph node cells and/or serum from immunized animals with severe lesions into histocompatible recipients rarely induced lesions in the recipients.
Footnotes
1 This paper is based on work supported in part by United States Public Health Service Training Grant 2T 01 DE00003-16 from the National Institute of Dental Research and performed in part under contract with the U. S. Atomic Energy Commission at the University of Rochester Atomic Energy Project and has been assigned Report No. UR-3490-338.
2 Present address: School of Dentistry, Center for the Health Sciences, Los Angeles, California 90024.
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