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Human J-Chain: Isolation and Molecular Weight Studies¹

From the Department of Immunology, Mayo Foundation School of Medicine, Rochester, Minnesota 55901

Abstract

J-chain was isolated from human IgA, SIgA and IgM by three different procedures. The simplest method was precipitation in water. The molecular weights were studied using two species plot analysis of the sedimentation equilibrium data. Two populations of molecules were found. One had a molecular weight of 13,300 to 17,700 and the other 6,400 to 11,500. These data are compared with those obtained by other investigators.

Footnotes

¹ This investigation was supported by Public Health Research Grant 2 RO1 AM 10419 from the National Institute of Arthritis and Metabolic Diseases; the American Cancer Society Grant IC-90; and the Arthritis Foundation.

² This work was done while Dr. Kang was on leave from the Department of Biochemistry, Catholic Medical College, Seoul, Korea.