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Thymus Dependence of Lymphocyte Trapping¹

From the Departments of Microbiology, Surgery and Pathology, Yale University School of Medicine, New Haven, Connecticut 06510

Abstract

Two models were employed to demonstrate the role of the thymus and T cells in antigen-induced lymphocyte trapping: 1) A graft-vs-host response (GVHR) of parental thymocytes to the antigens of lethally irradiated F₁ mice; 2) Challenge of T cell-deprived and reconstituted mice with sheep erythrocytes or keyhole limpet hemocyanin. In both experimental situations T cell-dependent augmented localization of ⁵¹Cr-labeled cells was demonstrable in the lymphoid tissues. Adult thymectomy and/or irradiation without T cell supplementation diminished, but did not always abrogate, the trapping response. In the GVHR, trapping preceded the peak DNA synthetic response of the parental thymocytes, and correlated with the dose of injected cells.

Footnotes

¹ This work was supported by the United States Public Health Service Grants CA 14216 and RR 05358, National Cancer Institute Grant CA-08593, National Institute for Arthritis and Infectious Diseases Grant AI-10497, Damon Runyon-Walter Winchell Cancer Fund Grant DRG 1208 and the American Cancer Society Grant ACS IN-31-L.

² Richard K. Gershon is a recipient of Research Career Development Award CA-10316 from the National Cancer Institute.