HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Gillette, R. W. Articles by Swanson, M. H. Search for Related Content PubMed Articles by Gillette, R. W. Articles by Swanson, M. H.

Effect of Concanavalin A on the Homing of Labeled T Lymphocytes¹

From Meloy Laboratories, Inc., Springfield, Virginia 22151

Abstract

Treatment in vitro with concanavalin A was found to alter markedly the distribution of ⁵¹Cr-labeled lymph node cells to the lymphoid organs of syngeneic recipient mice. The accumulation of labeled cells in recipient spleens was greatly increased at the expense of cell migration to the lymph nodes. This effect was abrogated by addition of a competitive inhibitor of concanavalin A. The data suggest that pyranoside groups on lymphocyte membranes are associated with the homing and recirculating properties of thymus derived cells.

Footnotes

¹ This work was supported by Contract NCI-E-72-3202 within the Virus Cancer Program of the National Cancer Institute.