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The Journal of Immunology, 1973, 111: 1887-1893.
Copyright © 1973 by The American Association of Immunologists, Inc.
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The Immune Response of Tetraparental Mice to Two Synthetic Amino Acid Polymers: "High-Conjugation" 2,4 Dinitrophenyl-Glutamic Acid57-Lysine38-Alanine5 (DNP-GLA5) and Glutamic Acid60 Alanine30 Tyrosine10 (Gat10)1

Carol M. Warner2, Maryann Fitzmaurice, Paul H. Maurer, Carmen F. Merryman and Mary Jo F. Schmerr

Iowa State University, Department of Biochemistry and Biophysics, Ames, Iowa 50010, and Thomas Jefferson University, Department of Biochemistry, Philadelphia, Pennsylvania 19107

Abstract

Allophenic (tetraparental) mice of the following types were produced: C57BL/6J {leftrightarrow} C3H/HeJ, C57BL/6J {leftrightarrow} DBA/1J, C3H/HeJ {leftrightarrow} CF1, C3H/HeJ {leftrightarrow} DBA/1J, C57BL/6J {leftrightarrow} BALB/cJ, SJL/J {leftrightarrow} C3H/HeJ, SJL/J {leftrightarrow} DBA/2J, SJL/J {leftrightarrow} C57BL/6J, and DBA/1J {leftrightarrow} A/J. These mice were immunized with 35 or 77 µg of "high-conjugation" (50 to 75%) 2,4 dinitrophenyl-poly (glu57 lys38 ala5), DNP-GLA5, or with 10 µg of poly (glu60 ala30 try10), GAT10. The primary and secondary antibody responses to the DNP group or GAT10 were tested. Many of the mice expressing the presence of "responder" cells, as shown by coat color phenotype, failed to respond to these antigens. We suggest two possible explanations: 1) An allophenic mouse may need a minimum number of responder lymphoid cells in order to respond to an antigen. 2) Cross-tolerance may be responsible for the non-response to some antigens in some strains of mice.

Footnotes

1 This work was supported by grants from Iowa State University, The Research Corporation, The Population Council, and by National Institutes of Health Research Grant AI 07825 and American Cancer Society Grant T-452.

2 Send correspondence to: Carol M. Warner, Department of Biochemistry and Biophysics, Iowa State University, Ames, Iowa 50010.






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