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Quantitative Phagocytosis by Neutrophils

II. Release of the C5-Cleaving Enzyme and Inhibition of Phagocytosis by Rheumatoid Factor¹

From the Department of Pathology, University of Connecticut Health Center, Farmington, Connecticut 06032, and the Department of Medicine, University of California, San Diego School of Medicine, La Jolla, California 92037

Abstract

By using the radiolabeled immune complex method for studying phagocytosis by neutrophils, release of the following lysosomal enzymes has been demonstrated: the C5-cleaving enzyme, glucuronidase, and acid phosphatase. Enzyme release is directly proportional to cell uptake of immune complexes and is suppressed in antigen excess. It has also been shown that human IgM rheumatoid factor, but not IgM lacking in rheumatoid factor activity, inhibits phagocytic uptake of immune complexes and, correspondingly, depresses the release of lysosomal enzymes.

Footnotes

¹ This work was supported in part by National Institutes of Health Grants AI-09651 and AM-14916. This is publication 46 from the Department of Pathology, the University of Connecticut Health Center, Farmington, Connecticut 06032.

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