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Immune Complex Glomerulonephritis in One-Year-Old C57BL/6 Mice Induced by Endogenous Murine Leukemia Virus and Erythrocyte Antigens¹

From the Department of Pathology, University of California School of Medicine, Los Angeles, California 90024

Abstract

Aging mice frequently develop a glomerulosclerosis; the severity of the lesion varies among mouse strains and increases with age. The kidneys of fifty 1-year-old C57BL/6 mice were examined and 48 had histologic evidence of mild to moderate intercapillary glomerulosclerosis. All fifty mice had glomerular deposits of IgG and 41 had deposits of C3 which were located in the mesangial zone and along glomerular capillary walls. Fifty to 57% of the kidney-bound immunoglobulin which was eluted reacted with murine leukemia virus cell surface antigen, while 8 to 37% of the immunoglobulin reacted with syngeneic erythrocytes. The glomerulosclerosis of aging C57BL/6 mice appears to be an immune complex glomerulonephritis induced by murine leukemia virus antigens, and to a lesser extent, erythrocyte antigens.

Footnotes

¹ This work was supported by Cancer Research Funds of the University of California and Grant AI-09476 from the National Institute of Allergy and Infectious Disease, National Institutes of Health. Presented at the annual meeting of the American Association of Immunologists, Atlantic City, New Jersey, April 1973 (Fed. Proc., 32: 964, 1973).

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