HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Oldstone, M. B. Articles by Dixon, F. J. Search for Related Content PubMed Articles by Oldstone, M. B. Articles by Dixon, F. J.

Change in Susceptibility of C3H/HeJ Mice to LCM Virus Infection¹

From the Department of Experimental Pathology, Scripps Clinic and Research Foundation, La Jolla, California 92037

Abstract

Mice infected with lymphocytic choriomeningitis (LCM)³ virus are a useful model for understanding the pathogenesis of disease associated with both acute and chronic virus infections (1, 2). In this model, tissue injury is caused by the interaction of the host's anti-viral immune response with virus or virus-infected cells. In acute infection, injection of adult mice with LCM virus leads either to recovery or death depending on the dose of virus administered, the route of inoculation used, and the ability of the host to mount an anti-viral immune response (3, 4). In chronic infection, the time scale of the response to LCM virus is lengthened and the severity of disease is related to the location and amount of LCM virus carried, the magnitude of the anti-viral antibody response made, and the interaction between virus and antibody (5).

In our initial studies on the pathogenesis of disease associated with LCM virus infection, we studied the susceptibility of different murine strains to LCM virus (5–7).

Footnotes

¹ This is publication number 734 from the Department of Experimental Pathology, Scripps Clinic and Research Foundation, La Jolla, California. This research was supported by United States Public Health Service Grants AI-09484 and AI-07007.

³ Abbreviations used in this paper: LCM, lymphocytic choriomeningitis; IC, intracerebrally.

² Recipient of Career Development Award AI-42580 AID from the United States Public Health Service.

This article has been cited by other articles:

				M. Oldstone, Y. Sinha, P Blount, A Tishon, M Rodriguez, R von Wedel, and P. Lampert Virus-induced alterations in homeostasis: alteration in differentiated functions of infected cells in vivo Science, December 10, 1982; 218(4577): 1125 - 1127. [Abstract] [PDF]