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Detection of Slow Reacting Substance of Anaphylaxis (SRS-A) in Plasma of Guinea Pigs during Anaphylaxis¹

From the Departments of Medicine, Harvard Medical School and the Robert B. Brigham Hospital, Boston, Massachusetts 02120

Abstract

SRS-A, a mediator long recognized to be released into the diffusates and perfusates from isolated tissues after antigen-antibody interaction, has been isolated from the plasma of sensitized guinea pigs challenged intravenously with specific antigen. Techniques are now available to study SRS-A release in vivo in selected immediate hypersensitivity reactions.

Footnotes

¹ Supported by Grant AI-07722 from the National Institutes of Health.

² Recipient of Research Career Development Award AI-28405 from the National Institutes of Health.

³ Present position: Chief, Department of Immunology, The Hospital for Sick Children at the University of Toronto, Toronto, Canada.