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Lymphocyte Populations of AKR/J Mice

II. Effect of Leukemogenesis on Migration Patterns, Response to PHA, and Expression of Theta Antigen¹

From the Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York 10461

Abstract

The present study describes abnormalities that occur in the lymph node, spleen, thymus, and blood lymphocytes of two distinct types of leukemic AKR/J mice. These two types, designated A and B leukemia, occur in a ratio of 3:1 in mice aged 7 to 10 months. Type A leukemic mice are characterized by the presence of a thymoma and enlarged peripheral lymphoid organs, and lymphocytes which 1) fail to migrate to lymph nodes, 2) exhibit normal transformation in response to PHA, and 3) have elevated sensitivity to anti-theta () serum. Type B leukemic mice have an atrophic thymus and elarged peripheral lymphoid organs; their lymphocytes 1) fail to home to lymph nodes, 2) exhibit decreased transformation in response to PHA, and 3) have decreased sensitivity to anti- serum. The significance of the dissociation of thymus-dependent characteristics, e.g., lymphocyte recirculation, response to PHA, and expression of the antigen, observed in type A leukemic lymphocytes, as well as the possible origins of type A and B leukemic lymphocyte populations, are discussed.

Footnotes

¹ This work was supported by grants from the United States Public Health Service (RO1CA14108) and the Damon Runyon Fund (DRG 1208).

² Marion Zatz was a recipient of a Damon Runyon Fund postdoctoral fellowship at the time this work was performed. Present address: Departments of Surgery and Microbiology, Yale University School of Medicine, New Haven, Connecticut 06510.

³ Present address: Syntex Research, Stanford Industrial Park, Palo Alto, California 94304.

⁴ Allan L. Goldstein was a recipient of a Career Development Award from the Public Health Council of the city of New York, at the time this work was performed. Present address: Division of Biochemistry, University of Texas Medical Branch, Galveston, Texas 77550.