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Lymphocyte Populations of AKR/J Mice

I. Effect of Aging on Migration Patterns, Response to PHA and Expression of Theta Antigen¹

From the Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York 10461

Abstract

The present study describes changes which occur in the lymph nodes, spleen, and thymus lymphocytes of aging AKR/J mice. Lymphocytes from mice between 3 and 14 months of age were investigated with respect to three thymus-dependent properties, i.e., in vivo homing to lymph nodes, responsiveness to phytohemagglutinin, and expression of the AKR antigen. Decreases in the numbers of lymph node-seeking, recirculating lymphocytes in lymph node, spleen, and thymus, and diminished responsiveness of spleen cells to stimulation by phytohemagglutinin were observed with increasing age. No change in the sensitivity of lymph node cells to anti- serum was noted in the aging AKR/J mice.

The significance of the decline in the size of the thymus-dependent recirculating lymphocyte pool with age is considered in relation to the concomitantly occurring onset of spontaneous lymphocytic leukemia, which is characteristic for the AKR/J strain.

Footnotes

¹ This work was supported in part by grants from the American Cancer Society (E-613), the National Institutes of Health (CA12060), and the Damon Runyon Fund (DRG 1208).

² Marion Zatz was a recipient of a postdoctoral fellowship from the Damon Runyon Memorial Fund for Cancer Research at the time this work was performed. Present address: Departments of Surgery and Microbiology, Yale University School of Medicine, New Haven, Connecticut 06510.

³ Allan L. Goldstein was a recipient of a Career Scientist Award from the Health Research Council of the City of New York at the time this work was performed. Present address: Department of Human Biological Chemistry and Genetics, Division of Biochemistry, The University of Texas Medical Branch, Galveston, Texas 77550.

⁴ Present address: Syntex Research, Stanford Industrial Park, Palo Alto, California 94304.

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