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Studies of Thoracic Duct Lymphocytes of Mice¹

III. Cell Surface Antigen Characteristics

From the Department of Surgery, Case Western Reserve Medical School, Cleveland, Ohio 44106, and the Division of Immunology, Sloan Kettering Institute for Cancer Research, New York, New York 10021

Abstract

Thoracic duct cells have a surface antigenic configuration determined by cytotoxic testing that is positive for H-2^d, , Ly-A, MSLA, , and µ antigens and negative for TL and PC antigens. Comparison of these results with other lymphoid elements, benign and malignant, reveals that thoracic duct cells resemble lymph node lymphocytes rather than thymocytes. Quantitative absorption analysis showed similar concentrations of the H-2^d, , and Ly-A antigens of thoracic duct and lymph node lymphocytes.

The findings suggest that the thoracic duct population is a composite of both thymic and bone marrow-derived cells. This antigenic heterogeneity is supported by both functional and morphologic studies.

Footnotes

¹ This study was supported by National Cancer Institute Grant CA 08748 and a grant from the John A. Hartford Foundation, Inc., and by the Blywise Fund of University Hospitals of Cleveland.

² Present address: Department of Surgery, Case Western Reserve Medical School, Cleveland, Ohio, 44106.

³ Present address: Division of Immunology, Sloan-Kettering Institute for Cancer Research, New York, New York 10021.