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The Journal of Immunology, 1973, 111: 1444-1449.
Copyright © 1973 by The American Association of Immunologists, Inc.
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Complement Receptors on Cell Membranes

I. Evidence for Two Complement Receptors1

Hidechika Okada and Kusuya Nishioka

From the National Cancer Center Research Institute, Tsukiji, Tokyo, Japan

Abstract

On DEAE-cellulose column chromatography, two fractions were obtained from mouse plasma. One made EA(IgM)C42 reactive to human erythrocytes but not to Daudi cells, a cultured cell line derived from Burkitt lymphoma. The addition of the other fraction to these intermediate complexes of complement on cells diminished adherence to human erythrocytes but generated adherence to Daudi cells. From these results we conclude that the receptors on human erythrocytes and on Daudi cells react differently with the intermediate complexes of complement.

Footnotes

1 This work was supported by research grants from the Ministry of Health and the Ministry of Education of the Japanese Government.






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