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Reversible Inhibition of Lymphocyte-Mediated Cytolysis by Dimethyl Sulfoxide (DMSO)

From the Department of Experimental Therapy, Wellcome Research Laboratories, Research Triangle Park, North Carolina 27709

Abstract

Dimethyl sulfoxide (DMSO) was found to inhibit reversibly in vitro lymphocyte-mediated, but not serum antibody-mediated cytolysis. Evidence is presented that the inhibition involves the prevention of productive interaction (i.e., contact which leads to lysis) and that DMSO does not inhibit the later events of the lytic cycle. Immunosuppressive activity could not be demonstrated in vivo presumably due to the inability to sustain high levels of DMSO. DMSO was used to estimate the time from interaction to lysis of target cell.

Footnotes

¹ Present address: Box 2735, Duke University Medical School, Durham, North Carolina.

² Present address: Box 2882, Duke University Medical School, Durham, North Carolina.

This article has been cited by other articles:

				G Wolberg, T. Zimmerman, K Hiemstra, M Winston, and L. Chu Adenosine inhibition of lymphocyte-mediated cytolysis: possible role of cyclic adenosine monophosphate Science, March 14, 1975; 187(4180): 957 - 959. [Abstract] [PDF]