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Induction of Cell-Mediated Immunity and Tolerance to Homologous Collagen in Guinea Pigs: Demonstration of Antigen-Reactive Cells for a Self-Antigen¹

From the Departments of Biochemistry and Surgery, University of California, San Francisco, California 94143

Abstract

Although normal guinea pigs exhibit no immunity against heterologous (human, mouse) and homologous collagens, cell-mediated immunity to these collagens can be induced in these animals after immunization with a heterologous (human) or the homologous (guinea pig) collagen in Freund's complete adjuvant. Furthermore, guinea pigs may be made specifically tolerant of their own collagen, and such tolerance is not broken by the subsequent induction of cellular immunity to a cross-reacting antigen, the human collagen. These results demonstrate the presence in guinea pigs of antigen-reactive cells capable of recognizing a self-antigen, with the possibility of subsequent induction of either immunity or tolerance, and argue against the assumption that self-tolerance is due to the absence of specific antigen-recognition cells.

Footnotes

¹ This study was supported in part by United States Public Health Service Grants, GM-18470, AM-16213, and HL 14759.

² Present address: Department of Clinical Pathology and Laboratory Medicine, San Francisco General Hospital, Clinical Laboratories Building 100, San Francisco, California 94110.

³ Recipient of Research Career Development Award 5-K4-AM-50205 from the National Institutes of Health.