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Vitamin A: Adjuvant and Steroid Antagonist in the Immune Response

From the Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20014 and Division of Plastic Surgery, Medical College of Virginia, Richmond, Virginia

Abstract

The effects of vitamin A and hydrocortisone on the immune response have been studied in the mouse. Vitamin A treatment alone markedly increases the normal number of antibody-forming cells generated in the spleen in response to immunization with sheep red blood cells. The antibody response to immunization with dinitrophenylated ovalbumin (DNP-OVA), a hapten-protein conjugate, is also enhanced by vitamin A pretreatment. Furthermore, the immunosuppressive effect of hydrocortisone on the response to sheep red blood cells can be prevented by simultaneous administration of vitamin A.

Footnotes

¹ Please address correspondence and reprint requests to: Dr. Benjamin E. Cohen, Massachusetts General Hospital, Fruit Street, Boston, Massachusetts 02114.

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