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The Journal of Immunology, 1973, 111: 996-1004.
Copyright © 1973 by The American Association of Immunologists, Inc.
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Antinucleolar Antibodies in Human Sera1

Jacob L. Pinnas2, James D. Northway3 and Eng M. Tan4

From the Division of Allergy and Immunology and Department of Experimental Pathology, Scripps Clinic and Research Foundation, La Jolla, California 92037

Abstract

Antibodies to mammalian cell nucleoli occur spontaneously in certain autoimmune human diseases and have been demonstrated by immunofluorescence. In this study, nucleoli were isolated from fresh calf thymus and antinucleolar antibodies were used as reagents to identify a reactive nucleolar antigen. The antigen was a low molecular weight 4–6S RNA, and the precipitating activity of this antigen was destroyed by treatment with spleen phosphodiesterase. Sera were selected for this study because of predominance of nucleolar staining by immunofluorescence and were found to be from patients with scleroderma, Sjogren's syndrome, and undiagnosed illnesses manifesting Raynaud's phenomenon.

Footnotes

1 Presented in part at the Annual Meeting of the American Rheumatism Association, Dallas, Texas, June, 1972. This is publication number 704 from the Department of Experimental Pathology, Scripps Clinic and Research Foundation, La Jolla, California. This work was supported by United States Public Health Service Grants AM 12198 and AI 00214 from the National Institutes of Health.

2 National Institutes of Health postdoctoral trainee. Present address Department of Medicine, University of Arizona School of Medicine, Tucson, Arizona.

3 Present address Department of Pediatrics, University of Indiana School of Medicine, Indianapolis, Indiana.

4 Senior Investigator, The Arthritis Foundation.






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