HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Howe, M. Articles by Cohen, L. Search for Related Content PubMed Articles by Howe, M. Articles by Cohen, L.

Relationship between Proliferative and Effector Phases of the Mixed Lymphocyte Reaction and Graft-Vs-Host Reaction¹

From the Department of Microbiology and Immunology, State University of New York, Brooklyn, New York 11203

Abstract

Spleen and thymus cells from BALB mice were shown to undergo proliferation in the mixed lymphocyte reaction and graft-vs-host reaction in response to antigens of H-2 identical DBA mice without generating effector lymphocytes exhibiting specific cytotoxicity for DBA target cells. Both proliferation and generation of cytotoxicity occurred when BALB lymphocytes were exposed to antigens of H-2 non-identical CBA mice. The proliferative response of BALB thymocytes to CBA antigens greatly exceeded that of BALB spleen cells, even though the generation of cytotoxic lymphocytes was greater in the spleen population. These data suggest that the proliferative and effector phases of the mixed lymphocyte reaction and the graft-vs-host reaction may be mediated by separate lymphoid cell populations having differing antigen requirements for activation.

Footnotes

¹ This investigation was supported by Research Grant AI 10158-02 from the United States Public Health Service.