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₂-Microglobulin in Human Blood Cells¹

From the Institute of Medical Chemistry, University of Uppsala, Box 551, 751 22 Uppsala, Sweden

Abstract

₂-Microglobulin has been solubilized from human blood cells by sonication, deoxycholate treatment, or acidification. The average number of ₂-microglobulin molecules per cell, measured after acidification, was 0.54 x 10⁵ for platelets, 18 x 10⁵ for mononuclear cells, and 6.9 x 10⁵ for polymorphonuclear cells. No ₂-microglobulin was detected in red blood cells. A relatively large proportion of the protein in platelets and mononuclear cells was located on the cell surface as compared with polymorphonuclear cells, according to experiments performed with ¹²⁵I-labeled rabbit anti-₂-microglobulin IgG.

Footnotes

¹ This work was supported by AB Pharmacia, Uppsala, Sweden, by the Swedish Medical Research Council (project No. 13X-512 and No. 13X-4), by the Swedish Cancer Society (project No. 53), and by Konung Gustav V:s 80-årsfond.

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