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Carrier Independent T Cell Helper Effects in Antigenic Stimulation¹

From the Department of Pathology, The University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19174

Abstract

Anti- serum treatment of cells from immunized mice before their transfer to irradiated non-immune recipients decreased the ability of such cells to be stimulated by hapten on both homologous and heterologous carriers over a wide range of antigen doses. The anti- treatment was shown to affect only thymus-dependent (T) cells, since the number of bone marrow-derived (B) cell precursors was unaltered. Thus, specific T cells contribute significantly, not only to stimulation by the hapten on the homologous carrier, but also when hapten is presented on heterologous and even poorly immunogenic carriers. These results are interpreted as indicating a role for collaborative interactions of hapten-specific T cells with B cells specific for the same determinant. Such interactions were found at low antigen concentration. Results are discussed with relation to the mechanism of B cell stimulation.

Footnotes

¹ This work was supported by Research Grant AI-08778 and Training Grant CA-05022 from the United States Public Health Service.

² This work is taken, in part, from a thesis submitted to the University of Pennsylvania Graduate School of Arts and Sciences in partial fulfillment of the requirements for the Doctor of Philosophy degree.

³ Recipient of a United States Public Health Service career development award (1-KO4-AI 33983) from the National Institute of Allergy and Infectious Diseases.