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The Journal of Immunology, 1973, 111: 1119-1127.
Copyright © 1973 by The American Association of Immunologists, Inc.
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Stimulation of {gamma}-Globulin Synthesis and Specific Antibody Production by a Factor Released by Activated Lymphocytes1

Moshe Rosenthal2, Peter Stastny3 and Morris Ziff4

From the Department of Internal Medicine, The University of Texas Southwestern Medical School, Dallas, Texas 75235, and the Dallas Veterans Administration Hospital

Abstract

By using a radioactive immune coprecipitation technique, supernatants of lymph node cells from immunized rabbits incubated with keyhole limpet hemocyanin (KLH) were shown to enhance {gamma}-globulin synthesis and anti-KLH antibody production of KLH-primed and nonprimed lymphoid cells from the peripheral blood and lymph nodes in the presence of KLH in vitro. Similarly, when KLH-stimulated supernatants were added both to BSA-primed and nonprimed lymphocyte cultures in the presence of BSA, increases in {gamma}-globulin and anti-BSA synthesis were observed. The data presented provide evidence that a soluble factor is released by antigen-stimulated lymphocytes which enhances immunoglobulin and specific antibody production in a nonspecific manner. The evidence obtained suggests that the factor may be a lymphokine which either directly or indirectly stimulates bone marrow-derived lymphocyte function in both the primary and secondary responses.

Footnotes

1 This work was supported by United States Public Health Service Grant AM-09989.

2 Arthritis Foundation Postdoctoral Fellow.

3 Veterans Administration Clinical Investigator.

4 Recipient, United States Public Health Service Research Career Award, National Institute of Arthritis, Metabolic and Digestive Diseases.






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