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Association of Tumor and Histocompatibility Antigens in Sera of Lymphoma-Bearing Mice

From the Department of Immunology, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada

Abstract

Soluble tumor-associated antigens and histocompatibility antigens were detected in sera of A/J mice bearing a spontaneous lymphoma (L1117) by the inhibition of the cytotoxicity of rabbit anti-L1117 serum and of alloantisera to normal A/J antigens, respectively; the rabbit antiserum was rendered specific for lymphoma antigens by extensive absorption with normal A/J cells and alloantisera were produced in C57BL/6J and C3H mice. Both types of antigen were isolated together from serum of tumor-bearing animals, with reverse immunosorbents prepared by insolubilization of either rabbit anti-L1117 antibodies or of the anti-A/J alloantibodies, and were also present in the supernatant of the medium used for culturing L1117 cells. It is suggested that the determinants responsible for these two antigenic specificities were associated with the same molecular moiety.