HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Maurer, P. H. Articles by Merryman, C. F. Search for Related Content PubMed Articles by Maurer, P. H. Articles by Merryman, C. F.

Genetic Control of the Immune Response in Guinea Pigs to the Known Sequence Polymer (Tyr-Glu-Ala-Gly)_n^1,2,

From the Department of Biochemistry, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107

Abstract

The immune response in guinea pigs against the known sequence polymer, (tyr-glu-ala-gly)_n has been studied. Hartley guinea pigs and inbred strain 13 guinea pigs react against the polymer (cellular and humoral responses) but strain 2 guinea pigs do not. Breeding studies have established that the response is controlled by a single dominant gene and that the locus involved is also linked to the major histocompatibility locus of the species.

Footnotes

¹ This work was supported by Research Grant AI 02825 from the National Institute of Allergy and Infectious Diseases, GM 15574 from the National Institute of General Medical Sciences, and T-452A from the American Cancer Society.

² Nomenclature of polymers is based upon recommendation of IUPAC-IUB Commission on Nomenclature, October 1967 (Biochem. J., 106: 577, 1968). Superscript is mol. ratio of amino acid in the random polymers. Abbreviations for amino acids used as follows: T, tyrosine; G, glutamic acid; A, alanine; L, lysine.