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Graft-vs-Host Reaction with an H-2 Mutant¹

From the Department of Oral Biology, University of Michigan, Ann Arbor, Michigan 48104, and the Institute of General Genetics, Academy of Sciences U.S.S.R., Moscow 117312, U.S.S.R.

Abstract

GVHR can be induced across the H-2D locus, presumably uncontaminated by any other genetic differences (Ir); it can also be induced across differences that do not have any histocompatibility effect on skin grafts. This is interpreted as evidence for two types of genes in the H-2 complex, H-genes involved in both GVHR and skin graft rejection, and Gvh-genes involved in GVHR but not in skin graft rejection.

Footnotes

¹ This work was supported by United States Public Health Service Research Grants GM-15419 and DE-02731.

² University of Michigan.

³ Institute of General Genetics.