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The Cellular Basis of Cross-Tolerance¹

From The Department of Experimental Pathology, Scripps Clinic and Research Foundation, La Jolla, California 92037

Abstract

Mice made unresponsive to human -globulin demonstrate a marked cross-tolerance to porcine -globulin and equine -globulin but react normally to the more phylogenetically distinct chicken -globulin. This cross-tolerance exists in spite of an antigenic cross-reactivity at the indirect plaque-forming cell level of only 1 to 3%. This cross-tolerance status can be transferred to thymectomized, irradiated, bone marrow-reconstituted recipients by tolerogen-treated thymus cells. It is suggested that antigen recognition by the thymus-derived cell manifests a wider range of cross-reactivity than that evidenced by the bone marrow-derived cell.

Footnotes

¹ This is Publication No. 692 from the Department of Experimental Pathology, Scripps Clinic and Research Foundation. The work was supported by the United States Public Health Service Grant AI 07007, American Cancer Society Grant IC-58B, and Atomic Energy Commission Contract AT (04-3)-410.

² Supported by United States Public Health Service Grant GM 02054-04.

³ Supported by a Dernham Fellowship (No. D-202) of the California Division of the American Cancer Society.

⁴ Supported by United States Public Health Service Research Career Award 4-K6-GM-06936-11.