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RNA-Mediated Immunologic Depression¹

From the Department of Experimental Leukemia, Instituto de Investigaciones Hematológicas, Academia Nacional de Medicina, Las Heras 3092, Buenos Aires, Argentina

Abstract

RNA extracted from normal liver had a specific immunodepressive effect in syngeneic BALB mice when administered 1 or 5 days before the antigen, as demonstrated in three different systems: 1) syngeneic leukemic colonization was accelerated and death anticipated; 2) spleen lymphocytes cultured in vivo within Millipore chambers showed a lower rate of spontaneous blastogenesis and lack of response to phytohemagglutinin; 3) after immunization with sheep red blood cells, spleen lymphocytes had a decreased rosette-forming capacity and the titer of hemagglutinins in serum was lower. It can be concluded that RNA pretreatment affects both cellular and humoral components of the immunologic system; the effect would be exerted on macrophages and/or lymphocytes.

Footnotes

¹ This research was supported by Consejo Nacional de Investigaciones Clientificas y Técnicas and Fundación para Combatir la Leucemia. Abridged from a Doctorate Thesis presented at the Universidad Nacional de Buenos Aires (M. E. M. C.).

² Member of the Research Career of Consejo Nacional de Investigaciones Científicas y Técnicas.

³ Research Fellow, Academia Nacional de Medicina.

⁴ Director, Instituto de Investigaciones Médicas, Rosario, Argentina.