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Alterations in Lymphocyte Populations in Tumorigenesis

I. Lymphocyte Trapping¹

From the Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York 10461

Abstract

Studies have been conducted of the migration of ⁵¹Cr-labeled lymph node cells into the lymphoid tissues of mice inoculated with the Moloney sarcoma virus. Significant numbers of labeled cells were trapped in the draining lymph nodes and spleens of tumor-bearing mice. The kinetics of lymphocyte trapping correlated with the cycle of growth and spontaneous regression which is characteristic of this tumor in healthy mice. Trapping first occurred after injection of the virus and maximal retention of lymphocytes corresponded to the time of tumor regression.

Footnotes

¹ This work was supported in part by the American Cancer Society (E-613), the National Institutes of Health (CA 12060), and the Damon Runyon Fund (DRG 1208).

² Marion M. Zatz was a recipient of a postdoctoral fellowship from the Damon Runyon Memorial Fund for Cancer Research at the time this work was performed. Present address: Department of Microbiology, Yale University School of Medicine, New Haven, Connecticut 06510.

³ Present address: Syntex Research, Stanford Industrial Park, Palo Alto, California 94304.

⁴ Allan Goldstein was a recipient of a Career Scientist Award from the Health Research Council of the City of New York at the time this work was performed. Present address: Division of Biochemistry, The University of Texas Medical Branch, Galveston, Texas 77550.