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Effects of Sublethal Irradiation on the Plaque-Forming Cell Response in Mice¹

From the Department of Experimental Pathology, Scripps Clinic and Research Foundation, La Jolla, California 92037

Abstract

X-ray (440 R) administered 4 days after a primary injection of 1 x 10⁸ sheep red blood cells (SRBC) into normal BALB/c mice resulted in increased numbers of indirect plaque-forming cells per million spleen cells (PFC/10⁶) 3 days after a secondary challenge of 1 x 10⁸ SRBC. The results were compared to control, non-x-rayed mice. The time of x-ray in relation to SRBC injection was critical as x-ray 3, 5, or 6 days after primary SRBC injection did not increase the number of PFC/10⁶ cells. The state of increased responsiveness induced by x-ray was dependent on the dose of SRBC used for primary injection and could not be transferred by spleen cells to syngeneic recipient mice. The number of primary direct PFC/10⁶ cells was increased when the response was measured 8 days after injection of SRBC and mice x-rayed 48 hr after antigen injection when compared to control non-x-rayed mice; this increase was probably due to a delay in the response induced by x-ray.

Footnotes

¹ This is publication No. 671 from the Department of Experimental Pathology, Scripps Clinic and Research Foundation, La Jolla, California 92037. This research was supported by Atomic Energy Commission Contract AT(04-3)-410 and United States Public Health Service Grant AI-07007.

² Recipient of United States Public Health Service Training Grant 5T1GM683. Present address: Department of Surgery, University of Minnesota, Minneapolis, Minnesota 55455.