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The Journal of Immunology, 1973, 111: 682-690.
Copyright © 1973 by The American Association of Immunologists, Inc.
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Heart Autoantibodies in Mice: Genetic, Bacterial, and Age Determinants1

John H. Schwab and Roger R. Brown

From the Department of Bacteriology and Immunology, University of North Carolina, Medical School, Chapel Hill, North Carolina 27514

Abstract

IgM autoantibody specific for heart sarcolemma can be induced in the mouse by immunization with protoplast membranes from group A streptococci. An IgM autoantibody of similar specificity develops "spontaneously" with increasing age in non-immunized normal mice and reaches a very high incidence in old mice of certain inbred strains. Comparison of strains of A-congenic mice indicates that the production of this "spontaneous" autoantibody is associated with the H-2 locus. The genetic control is apparently dominant since the F1 hybrid of high and low incidence strains is also of high incidence. This antibody is independent of sex. IgM antisarcolemma antibody can be absorbed from both immunized and "spontaneous" sera with protoplast membranes from group A streptococci but not with group D membranes or group A cell walls. Antibody against group A streptococcal membranes, measured directly by membrane agglutination, is present in the serum of all old normal mice tested. These agglutinin titers do not correlate with heart autoantibody. The autoantibodies give no reaction with membranes in liver or kidney and much less reaction with skeletal muscle compared to heart. An IgM antinuclear autoantibody which gives a distinctive diffuse pattern of staining by indirect immunofluoresence is also induced by immunization with group A streptococcal protoplast membranes.

Footnotes

1 This work was supported by a grant-in-aid from the American Heart Association.






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