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The Responsiveness of Tolerant Lymphocyte Populations after Transfer to Normal Recipients¹

From the Trudeau Institute, Saranac Lake, New York 12983

Abstract

Thoracic duct lymphocytes taken from Lewis rats exhibiting tolerance of F₁ hybrid skin grafts can recirculate from blood to lymph in recipients syngeneic with the skin donors. They do so in a functionally active condition as evidenced by the ability of recirculating donor cells to cause a graft-vs-host reaction in recipient rats belonging to a second F₁ hybrid cross. This phenomenon was exploited in experiments designed to detect tolerant lymphocytes within cell populations that were either unresponsive or only feebly responsive to BN alloantigens. The results demonstrate that lymphocyte populations from tolerant donors retain approximately the same level of unresponsiveness when housed for up to 2 weeks in normal, non-tolerant recipients. Failure of the transferred cells to regain an appreciable level of responsiveness in these circumstances implies that tolerance to major histocompatibility antigens is a stable property of circulating lymphocytes, and lends support to the concept that tolerance induction involves either the selective deletion or permanent inactivation of antigen reactive cells.

Footnotes

¹ This work was supported by the Jacob C. Korb Memorial Grant for Cancer Research from the American Cancer Society and by Grant AI-08642 from the National Institute of Allergy and Infectious Diseases.

² Research Associate, American Cancer Society.