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The Journal of Immunology, 1973, 111: 667-671.
Copyright © 1973 by The American Association of Immunologists, Inc.
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Further Evidence for the Involvement of Thymus-Processed Lymphocytes in Syngeneic Tumor Cell Cytolysis

Fernando Plata, Elisabeth Gomard, Jean-Claude Leclerc and Jean-Paul Levy

From the Laboratoire d'Immunologie des Tumeurs, Institut de Recherches sur les Maladies du Sang, Centre Hayem, Hôpital Saint Louis, 75010 Paris

Abstract

The chromium-51 release test was used to study syngeneic tumor cell lysis by spleen lymphocytes from MSV tumor-bearing animals throughout the various stages of tumor growth and regression. Thymus dependent (T) cells were found to be necessary for tumor cell immune lysis to occur, and no requirement for non-T cells was detected.






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