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In Vitro Assessment of Cellular Immunity to Rauscher Leukemia Virus¹

From the Departments of Microbiology, Pennsylvania State University, University Park, Pennsylvania 16802 and Albert Einstein Medical Center, Philadelphia, Pennsylvania 19141

Abstract

Cell-mediated immunity to Rauscher leukemia virus (RLV) was studied utilizing the macrophage migration inhibition assay. Cell-mediated immunity to purified RLV antigen was detected in splenic lymphocytes of the leukemia resistant C57BL/6 mouse strain inoculated with infectious RLV. In contrast, no cellular immunity to RLV could be detected in splenic lymphocytes of the leukemia susceptible BALB/c mouse strain upon infection with RLV. Both strains of mice exhibited an active cell-mediated immune response following inoculation with heat-inactivated RLV. Appropropriate controls ruled out a contribution of either antibody or antibody-antigen complexes as mediators of the observed inhibition of macrophage migration. These data support the view that an inhibition of cell-mediated immune function may be a prerequisite to the induction of viral leukemia.

Footnotes

¹ This work was supported in part by American Cancer Society, Inc. Research Grant IC-19G.

² In partial fulfillment of the requirements for the degree of Doctor of Philosophy, Department of Microbiology, Pennsylvania State University.