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A New Serum Factor in Normal Rabbits

IX. Association with Group B Immunoglobulin Allotypic Specificities¹

From the Department of Microbiology, The University of Texas at Austin, Austin, Texas 78712

Abstract

The serum of b⁴b⁴ rabbits gave higher HR titers when tested with b⁴b⁴ or b⁹b⁹ fragments than when tested with fragments bearing the allelic b⁵ or b⁶ markers. Reciprocal results were obtained with serum from b⁵b⁵ or b⁶b⁶ rabbits. Thus, the heterogeneity noted in the HR titers for rabbits is dependent upon the group b L chain allotypic specificities.

The relationship between the group b allotypes and HR activity suggested that the specific Fab HR site required the proper alignment of the Fd piece with the L chain. This was confirmed by reduction-alkylation experiments which established the necessity for the L-H chain disulfide bond.

Footnotes

¹ This study was supported by United States Public Health Service Grant AI-07184 and Robert A. Welch Foundation Grant F-209.

² Recipient of a United States Public Health Career Development Award.