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Immune Responses in Vitro¹

VIII. Analysis of Cell Clusters

From the Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115

Abstract

We have demonstrated that hemolytic clusters which develop in cultures of mouse spleen cells stimulated with heterologous erythrocytes contain plaque-forming cells, but are not clonally restricted to production of antibody of one immunoglobulin class or against one antigenic specificity.

Footnotes

¹ This investigation was supported by United States Public Health Service Research Grant AI-09897 from the National Institute of Allergy and Infectious Diseases.

² Supported by Training Grant GM-01235 from the National Institutes of Health.

³ Recipient of United States Public Health Service Research Career Development Award 1K4-AI-70,173 from the National Institute of Allergy and Infectious Diseases.