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Immunologic Studies on Drug Addiction¹

I. Antibodies Reactive with Methadone and Their Use for Detection of the Drug

From the Department of Immunology, The Public Health Research Institute of The City of New York, Inc., New York, New York 10016

Abstract

Antisera which react with methadone and with urine from users of this drug have been prepared in rabbits. A simple and rapid hemagglutination-inhibition test which detects methadone in concentrations of 1 ng/ml has been applied to human urine specimens with results that demonstrate the specificity of the test and suggest that use of the drug may remain detectable for at least 1 week. Heroin used simultaneously with methadone does not interfere in the test.

Footnotes

¹ This work was supported in part by Contract DADA17-72C-2052, Department of Army, United States Army Medical Research and Development Command, Washington, D. C., and by Grant MH-21084 from the National Institute of Mental Health.