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Absence of Rosette-Forming Cells in Delayed Hypersensitive Agammaglobulinemic Chickens¹

From the Department of Pathology, New York University School of Medicine, 550 First Avenue, New York, New York 10016

Abstract

Delayed hypersensitivity was produced by immunization with sheep erythrocytes (SE) in adjuvants in bursectomized and normal chickens and the numbers of rosette-forming cells (RFC) in the spleen were determined. It was found that RFC occurred only in animals with 0.1% of normal serum -globulin levels and that an increase over background was seen primarily after intravenous immunization with SE in such animals. RFC were not killed by specific rabbit anti-chicken thymus sera but were eliminated by treatment with anti-bursa or anti-chicken Ig sera in the presence of C. Incubation of cells with anti-Ig at 4°C also inhibited 100% of RFC. It was concluded that none of the RFC in the chicken are of thymic origin.

Footnotes

¹ This work was supported by Grant AI-3076 from the United States Public Health Service.

² Postdoctoral Fellow of the Arthritis Foundation. Send requests for reprints to: Dr. G. A. Theis, New York Medical College, Basic Science Building, Department of Pathology, Valhalla, New York 10595.

³ United States Public Health Service Senior COSTEP Research Associate, 39900.