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The Journal of Immunology, 1973, 111: 317-323.
Copyright © 1973 by The American Association of Immunologists, Inc.
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Induction of Tolerance to a Hapten

II. Maintenance and Escape of the Tolerant State to TNP1

John M. Fidler2 and Edward S. Golub3

From the Department of Biological Sciences, Purdue University, Lafayette, Indiana 47907

Abstract

A single injection of trinitrobenzenesulfonic acid (TNBS) induces a state of immunologic tolerance to the trinitrophenyl (TNP) hapten, which is specific and dose dependent. multiple injections of TNBS induce a longer lasting state of unresponsiveness than single injections. Escape from tolerance is characterized by the production of only 2-mercaptoethanol (ME)-sensitive (19S) anti-TNP antibody whether tolerance is induced by single or multiple injections. multiple injections of hapten-carrier conjugate (TNP-sheep erythrocytes) extend the duration of the tolerance induced by multiple injections of TNBS. The anti-TNP response of animals escaping from tolerance induced by multiple TNBS injections and extended by multiple hapten-carrier challenges consisted entirely of ME-sensitive (19S) antibody. Substitution of carrier for hapten-carrier conjugate in the initial challenge injection resulted in a normal anti-TNP response pattern in terms of class and temporal sequence of antibody produced during escape from tolerance. TNBS treatment had no effect upon the "accelerated" response to carrier induced by low-dose carrier priming, and TNBS treatment induced tolerance to TNP in low-dose carrier-primed mice.

Footnotes

1 This work was supported by United States Public Health Service Grant AI-08800.

2 Recipient of a David Ross Fellowship of Purdue University.

3 Recipient of a United States Public Health Service Career Development Award.






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