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Myelination Inhibition Factor: Its Absence in Sera from Subhuman Primates Sensitized with Myelin Basic Protein¹

From The Departments of Neurology (Veterans Administration Hospital Division) and Medical Microbiology, Stanford University School of Medicine, Stanford, California 94305 and the Department of Physiology and Institute of Human Development, University of California, Berkeley, California 94720

Abstract

Experimental allergic encephalomyelitis was induced in subhuman primates by inoculation with either whole monkey brain plus Freund's adjuvant or with purified bovine myelin basic protein combined with Freund's adjuvant. Sera from the whole brain-sensitized primates, when incorporated into tissue culture nutrient medium and applied continuously to cerebellar cultures from the day of explantation on, prevented the formation of myelin in the explants. Sera from basic protein-sensitized primates, on the other hand, failed to inhibit myelination when applied in like fashion to cerebellar tissue cultures, confirming a previous demonstration of a similar lack of myelination-inhibiting activity in sera from basic protein-sensitized guinea pigs. The results suggest that the tissue culture myelination inhibition factor is induced by a component of whole central nervous system tissue other than the encephalitogenic protein.

Footnotes

¹ This work was supported by Veterans Administration research funds, Grant NS-05513 from The National Institutes of Health and a grant from The National Science Foundation.

² Reprint requests should be directed to Dr. F. J. Seil, Department of Neurology (180), Veterans Administration Hospital, Palo Alto, California 94304.

³ NINDS Special Fellow 7 F11 NS 2173-01A1 NSRB in Neuropathology. Present address: Department of Pathology, University of California at Irvine.

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