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Effects of Pyran Copolymer on Leukemogenesis in Immunosuppressed AKR Mice¹

From the Harvard Medical School; Department of Medicine and Surgery, Massachusetts General Hospital and Sears Surgical Laboratories, Boston City Hospital, Boston, Massachusetts

Abstract

Treatment with anti-lymphocyte serum twice weekly from 4 months of age accelerated leukemogenesis in AKR mice. In contrast, monthly injections of Pyran copolymer retarded development of leukemia both in immunologically intact and suppressed animals of this strain. These studies provide further evidence for the absence of immunologic tolerance to viral or tumor antigens in AKR mice, and for the efficacy of Pyran copolymer as a prophylactic agent against virus-associated oncogenesis in immunosuppressed hosts.

Footnotes

¹ These investigations were conducted under Public Health Service Grants CA-12464-02 and AI08558-04, as well as under Contract NIH 72-2012 within the Special Virus Cancer Program of the National Cancer Institute, National Institutes of Health, United States Public Health Service.